PADI4 ELISA Kit (Human)
Catalog Number:
ASB-OKCD01879
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| Article Name: | PADI4 ELISA Kit (Human) |
| Biozol Catalog Number: | ASB-OKCD01879 |
| Supplier Catalog Number: | OKCD01879 |
| Alternative Catalog Number: | ASB-OKCD01879-96WELLS |
| Manufacturer: | Aviva |
| Category: | Kits/Assays |
| Application: | ELISA |
| Species Reactivity: | Human |
| Alternative Names: | HL-60 PAD,PAD,PAD4,PADI5,PADI-H protein,PDI4,PDI5,peptidyl arginine deiminase, type IV,peptidyl arginine deiminase, type V,Peptidylarginine deiminase IV,protein-arginine deiminase type IV,protein-arginine deiminase type-4. |
| Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at Arg-54 (to form H1R54ci), histone H3 at Arg-2, Arg-8, Arg-17 and/or Arg-26 (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at Arg-3 (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of Arg-54 of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at Arg-2142, which favors its interaction with NCOA2/GRIP1. |
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