FRE,frezzled,FRITZ,frizzled homolog-related,frizzled-related protein 1,FRP-3,FRZB1,FRZB-1,FRZB-PEN,FZRB,hFIZ,OS1,secreted frizzled-related protein 3,sFRP-3,SFRP3,SRFP3.
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.