GCCR,GCR,GCRST,glucocorticoid nuclear receptor variant 1,glucocorticoid receptor,GR,GRL,Nuclear receptor subfamily 3 group C member 1,nuclear receptor subfamily 3 group C member 1 variant hGR-B(54),nuclear receptor subfamily 3 group C member 1 variant hGR-B(77),nuclear receptor subfamily 3 group C member 1 variant hGR-B(93),nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor).
Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5 UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity).
