MTDPS8A,MTDPS8B,p53-inducible ribonucleotide reductase small subunit 2 homolog,p53-inducible ribonucleotide reductase small subunit 2 short form beta,p53-inducible ribonucleotide reductase small subunit 2-like protein,P53R2,ribonucleoside-diphosphate reductase subunit M2 B,ribonucleotide reductase M2 B (TP53 inducible),TP53-inducible ribonucleotide reductase M2 B.
Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
