dJ281H8.4,IDDM5,insulin-dependent diabetes mellitus 5,small ubiquitin-like modifier 4 protein,Small ubiquitin-like protein 4,small ubiquitin-related modifier 4,SMT3 suppressor of mif two 3 homolog 2,SMT3 suppressor of mif two 3 homolog 4,SMT3H4,SUMO-4.
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
