AMCBX2,CGD,CGD91-phox,CGDX,cytochrome b(558) subunit beta,cytochrome b-245 beta polypeptide,cytochrome b-245 heavy chain,cytochrome b558 subunit beta,GP91-1,GP91PHOX,GP91-PHOX,heme-binding membrane glycoprotein gp91phox,IMD34,NADPH oxidase 2,neutrophil cytochrome b 91 kDa polypeptide,NOX2,p22 phagocyte B-cytochrome,p91-PHOX,superoxide-generating NADPH oxidase heavy chain subunit.
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
