C15DUPq,cell proliferation-inducing gene 2 protein,CKTSF1B1,colorectal adenoma and carcinoma 1,CRAC1,CRCS4,cysteine knot superfamily 1, BMP antagonist 1,DAN domain family member 2,DAND2,down-regulated in Mos-transformed cells protein,DRM,DUP15q,GREMLIN,gremlin 1, cysteine knot superfamily, homolog,gremlin 1-like protein,gremlin-1,hereditary mixed polyposis syndrome,HMPS,HMPS1,IHG-2,Increased in high glucose protein 2,increased in high glucose-2,MPSH,PIG2.
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2, inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed:27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity).
