11-beta-HSD2,11-beta-hydroxysteroid dehydrogenase type 2,11-DH2,corticosteroid 11-beta-dehydrogenase isozyme 2,Hydroxysteroid dehydrogenase, 11 beta type 2,NAD-dependent 11-beta-hydroxysteroid dehydrogenase.
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.