late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MAP2K1IP1,MAPBP,MAPK scaffold protein 1,MAPKSP1,MEK binding partner 1,MEK-binding partner 1,mitogen-activated protein kinase kinase 1 interacting protein 1,Mitogen-activated protein kinase kinase 1-interacting protein 1,mitogen-activated protein kinase scaffold protein 1,MP1,PRO0633,ragulator complex protein LAMTOR3,Ragulator3.
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
