BM28,CCNL1,cdc19,CDCL1,cell devision cycle-like 1,cyclin-like 1,D3S3194,DFNA70,DNA replication licensing factor MCM2,minichromosome maintenance deficient 2 (mitotin),minichromosome maintenance protein 2 homolog,MITOTIN,nuclear protein BM28.
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis.
