9530036O11Rik,Dsh,hemimelic extra toes,Hhg1,HHG-1,Hx,Hxl3,M100081,shh unprocessed N-terminal signaling and C-terminal autoprocessing domains,ShhNC,short digits,sonic hedgehog protein.
Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (PubMed:8824192, PubMed:7891723). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (PubMed:8824192). Both activities occur in the reticulum endoplasmic (PubMed:21357747). Once cleaved, ShhC is degraded in the endoplasmic reticulum (PubMed:21357747).