CD120b,p75,p75 TNF receptor,p75TNFR,p80 TNF-alpha receptor,soluble TNFR1B variant 1,TBPII,TNFBR,TNFR1B,TNFR2,TNF-R2,TNF-R75,TNFR80,TNF-RII,TNF-R-II,tumor necrosis factor beta receptor,tumor necrosis factor binding protein 2,tumor necrosis factor receptor 2,tumor necrosis factor receptor superfamily member 1B,tumor necrosis factor receptor type II.
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
