apoptosis inducing protein TRICK2A/2B,apoptosis inducing receptor TRAIL-R2,CD262,cytotoxic TRAIL receptor-2,death domain containing receptor for TRAIL/Apo-2L,death receptor 5,DR5,Fas-like protein,KILLER,KILLER/DR5,p53-regulated DNA damage-inducible cell death receptor(killer),TNF-related apoptosis-inducing ligand receptor 2,TRAILR2,TRAIL-R2,TRICK2,TRICK2A,TRICK2B,TRICKB,tumor necrosis factor receptor superfamily member 10B,tumor necrosis factor receptor superfamily, member 10b,tumor necrosis factor receptor-like protein ZTNFR9,ZTNFR9.
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
