A1S9,A1S9T,A1S9T and BN75 temperature sensitivity complementing,A1ST,AMCX1,CFAP124,GXP1,POC20,POC20 centriolar protein homolog,Protein A1S9,SMAX2,testicular secretory protein Li 63,UBA1, ubiquitin-activating enzyme E1 homolog A,UBA1A,UBE1,UBE1X,Ubiquitin-activating enzyme E1,ubiquitin-like modifier-activating enzyme 1,VEXAS.
Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334).
