Osteoprotegerin acts as decoy receptor for rankl and thereby neutralizes its function in osteoclastogenesis. OPG inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local rankl/opg ratio. Osteoprotegerin may also play a role in preventing arterial calcification. May act as decoy receptor for trail and protect against apoptosis. Trail binding blocks the inhibition of osteoclastogenesis.
Greater than 90.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Form:
OPG was lyophilized from a 0.2um filtered concentrated solution in 20mM PB, pH 6.0, 150mM NaCl and 0.02 % Tween-80. Physical appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
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