Recombinant Human Factor VIII Protein, Chinese Hamster
Biozol Catalog Number:
ASB-OPPA01234
Supplier Catalog Number:
OPPA01234
Alternative Catalog Number:
ASB-OPPA01234-250IU
Manufacturer:
Aviva
Host:
Chinese Hamster
Category:
Proteine/Peptide
Species Reactivity:
Human
Alternative Names:
AHF, F8B, F8C, HEMA, FVIII, DXS1253E
Coagulation factor VIII participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
