PGP9.5 Protein, E. coli

Product Overview

• Article Name: PGP9.5 Protein, E. coli
• Biozol Catalog Number: ASB-OPPA01450
• Supplier Catalog Number: OPPA01450
• Alternative Catalog Number: ASB-OPPA01450-5UG
• Manufacturer: Aviva
• Host: E. coli
• Category: Proteine/Peptide
• Species Reactivity: Human
• Alternative Names: NDGOA, PARK5, PGP95, SPG79, PGP9.5, Uch-L1, HEL-117, PGP 9.5, HEL-S-53

Product Description

UCHL1 (PGP9.5) belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product (PGP9.5) is a neuron specific protein, structurally and immunologically distinct from neuron specific enolase. Human UCHL1 and UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a proteins resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons and nerve fibers at all levels of the central and peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia and leydig cells of the testis, in ova and in some cells of both the pregnant and non pregnant corpus luteum. A point mutation (I93M) in UCHL1 is implicated as the cause of Parkinsons disease in one kindred. On the other hand, a polymorphism (S18Y) in UCHL1 has been found to be associated with a reduced risk for Parkinsons disease. Furthermore, UCHL1 is associated with the Alzheimers disease, and required for normal synaptic and cognitive function.

Product Properties

• Concentration: 1 mg/ml
• NCBI: 7345
• Purity: >95.0% as determined by SDS-PAGE.
• Form: Liquid- 20mM Tris-HCl buffer (pH 8.0) and 2mM EDTA.Physical appearance: Sterile Filtered clear solution.
• Sequence: MQLKPMEINP EMLNKVLSRL GVAGQWRFVD VLGLEEESLG SVPAPACALL LLFPLTAQHE NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLGFED GSVLKQFLSE TEKMSPEDRA KCFEKNEAIQ AAHDAVAQEG QCRVDDKVNF HFILFNNVDG HLYELDGRMP FPVNHGASSE DTLLKDAAKV CREFTEREQG EVRFSAVALC KAA.