Human cardiac troponin I is the inhibitory subunit of troponin involved in confering calcium sensitivity to muscle actomyosin ATPase activity. Mutation of the TNN13 gene can lead to familial hypotrophic cardiomyopathy 7 (CMH7), a hereditary heart condition characterized by asymetric ventricular hypertrophy. Other cardiomyopathies also occur as a result of mutations in the TNN13 gene.
