NFKBIA antibody - N-terminal region (P100940_P050), Rabbit, Polyclonal
Biozol Catalog Number:
ASB-P100940_P050
Supplier Catalog Number:
P100940_P050
Alternative Catalog Number:
ASB-P100940_P050-100UL, ASB-P100940_P050-25UL
Manufacturer:
Aviva
Host:
Rabbit
Category:
Antikörper
Application:
IHC, WB
Species Reactivity:
Human, Porcine
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human NFKBIA
Alternative Names:
IKBA, MAD-3, NFKBI, EDAID2
NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).
