Transforming Growth Factors alpha (TGF-alpha) is a 5.68 kDa member of the epidermal Growth Factors with 51 amino acid residues. TGF-alpha is mainly expressed from brain, skin, epithelial cell (pancreatic endocrine cells, urothelial cells, oligodendrocyte precursor cells, etc.). TGF-alpha is a regulator of cell proliferation and differentiation via bind to the EGFR and to act synergistically with TGF beta. TGF-alpha also associates with myriad forms of cancer.