Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. Many different types of cells can produce IL-10, including immune cells and non-immune cells. IL-10 exerts inhibitory functions on DCs and macrophages, which is a potent inhibitor of antigen presentation and limit the production of the Th1-associated cytokines IL-2 and interferon-gamma (IFN-gamma). IL-10 is also a key immunoregulator during infection due to its inhibitory effect on inflammatory cytokine production. Consequently, the excessive Th1 and CD8+ T cell responses could be suppressed during infection.
Molecular Weight:
The protein has a calculated MW of 19.7 kDa. The protein migrates as 19 kDa under reducing condition (SDS-PAGE analysis)
The protein was lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 7.4. If you have any concerns or special requirements, please confirm with us.
Sequence:
Amino acid sequence derived from Mouse IL-10(P18893)(Ser19-Ser178)was expressed with 6*His tag at the C-terminus.
Application Notes:
Mouse
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