C-C Motif Chemokine Ligand 2 (CCL2) is a 13.88 kDa cytokine with 125 amino acid residues and is also known as monocyte chemoattractant protein 1 (MCP1). CCL2 is mainly secreted from monocytes, macrophages, and dendritic cells. It regulates many biological functions, such as recruitments of monocytes, memory T cells, eosinophils, and dendritic cells, extravasation of helper T cells, response to TNFalpha and IFNgamma, and angiogenesis. In addition, upon binding with CCR4, it initiates leukocyte migration response to inflammation.
Molecular Weight:
The protein has a calculated MW of 14.65 kDa.The protein migrates as 17-25 kDa under reducing condition (SDS-PAGE analysis).