D2R (Rhodamine 110, bis-(L-aspartic acid amide), ditrifluoroacetic acid salt) is a general substrate for caspases including caspases 3 and 7. Unlike other fluorogenic substrates for caspases, D2R appears to be membrane-permeant, and thus can be used to measure caspase activity in live cells without osmotic shock for flow cytometry studies, as well as for cell extracts. For real-time detection of caspase-3 activity in intact cells, see NucView Caspase-3 Substrates. Ex/Em of end product (R110) = 496/520 nm Off-white to pink solid soluble in DMSO Store at 4C and protect from light C32H26F6N4O13 MW: 788.57
Source:
Synthetic
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