Recombinant human HPV16 E1/E4 fragment (aa 36-41).
Conjugation:
CF405S
Alternative Names:
HPV-16, HPV-16 capsid, HPV16 L1, HPV16 major capsid protein L1, Human papillomavirus type 16 L1, Human papillomavirus type 16 major capsid protein L1
The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a high-risk sexually-transmitted HPV that can lead to cervical, anal, vulvar, head, neck, and penile cancer. The HPV16E1/E4 protein is expressed abundantly in cells supporting viral DNA amplification, but is lost during malignant progression. HPV16E1/E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes. HPV16E1/E4 also interacts with cyclin A and Cdk2 during the G2 phase of the cell cycle, and this association may increase the efficiency with which HPV16E1/E4 is able to prevent mitotic entry. HPV16E1/E4 also associates with keratin intermediate filaments and causes the network to collapse. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Clonality:
Monoclonal
Concentration:
0.1 mg/mL
Clone Designation:
[HPV16 E1/E4]
Molecular Weight:
16 kDa
UniProt:
Not Applicable
Buffer:
PBS, 0.1% BSA, 0.05% azide
Source:
Animal
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