CD Mouse spleen and bone marrow cells enriched for NK-1 cells
Conjugation:
CF 740
Alternative Names:
CD161 antigen-like family member C, CD161c, Killer cell lectin-like receptor subfamily B member 1C (Klrb1c), Klrb1f, Lymphocyte antigen 55c (Ly55c), Lymphocyte antigen 59, Natural killer cell surface protein P1-40, NK1.1, NKR-P1 40, NKR-P1.9, NKR-P1C, NKRP1
NK1. 1 is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by theKlrb1c/NKR-P1Cgene. It is predominantly expressed as a disulfide-linked homodimer on NK cells however, it is also expressed on NK-T cells, a rare population of T lymphocytes. NK1. 1 is expressed in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allograftsin vivo. NK-1. 1 has also been shown to play a role in NK cell activation, IFN- production, and cytotoxic granule release. NK-1. 1 is commonly used as a mouse NK cell marker. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
