Plasma Cell Marker(LIV3G11, same as 7B18), 0.2mg/mL, IgG2a, Clone: [LIV3G11 same as 7B18], Mouse, Monoclonal
Biozol Catalog Number:
BOT-BNUB0047-500
Supplier Catalog Number:
BNUB0047-500
Alternative Catalog Number:
BOT-BNUB0047-500-500UL
Manufacturer:
Biotium
Host:
Mouse
Category:
Antikörper
Application:
IF, IHC
Species Reactivity:
Human
Immunogen:
Pancreatic cancer-related mucin
Alternative Names:
Plasma B cell, Plasmocytes
This antibody recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4 lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm, their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This MAb superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Note that this MAb is not suitable for staining frozen tissues. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Clonality:
Monoclonal
Concentration:
0.2 mg/mL
Clone Designation:
[LIV3G11 same as 7B18]
Molecular Weight:
Not Known
Isotype:
IgG2a
UniProt:
Not Known
Buffer:
PBS, 0.05% BSA, 0.05% azide
Source:
Animal
Application Notes:
Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Does not react with rat, others not known|Immunohistology formalin-fixed 0.1-0.2 ug/mL|Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes|Optimal dilution for a specific application should be determined by user
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