Macrophage Specific Antigen(LN-5), 0.2mg/mL, Clone: [LN-5], Mouse, Monoclonal
Biozol Catalog Number:
BOT-BNUB0059-500
Supplier Catalog Number:
BNUB0059-500
Alternative Catalog Number:
BOT-BNUB0059-500-500UL
Manufacturer:
Biotium
Host:
Mouse
Category:
Antikörper
Application:
IHC
Species Reactivity:
Human
Immunogen:
Human peripheral blood mononuclear cells
Alternative Names:
Not Known
This MAb stains the cytoplasm of macrophages and histiocytes in hematopoietic organs, Kupffers cells of the liver and Langerhans cells of the skin. Macrophages comprise of many forms of mononuclear phagocytes found in tissues. Mononuclear phagocytes arise from hematopoietic stem cells in the bone marrow. After passing through the monoblast and pro-monocyte states of the monocyte stage, they enter the blood, where they circulate for about 40 hours. They then enter tissues and increase in size, phagocytic activity, and lysosomal enzyme content becoming macrophages. Among the functions of macrophages are nonspecific phagocytosis and pinocytosis, specific phagocytosis of opsonized microorganisms mediated by Fc receptors and complement receptors, killing of ingested microorganisms, digestion and presentation of antigens to T and B lymphocytes, and secretion of a large number of diverse products, including many enzymes including lysozyme and collagenases, several complement components and coagulation factors, some prostaglandins and leukotrienes, and many regulatory molecules (Interferon, Interleukin 1). LN-5 selectively stains human sebaceous glands in formalin-fixed, paraffin-embedded skin samples. Undifferentiated sebocyte progenitors are negative, and only sebocytes from the onset of their differentiation reveal positive cytoplasmic staining.This antibody is available purified with BSA/azide at 200 ug/mL, or BSA/azide-free at 1 mg/mL.
Clonality:
Monoclonal
Concentration:
0.2 mg/mL
Clone Designation:
[LN-5]
Molecular Weight:
Not Known
UniProt:
Not Known
Buffer:
PBS, 0.05% BSA, 0.05% azide
Source:
Animal
Application Notes:
Immunofluorescence 0.5-1 ug/mL|Flow Cytometry 0.5-1 ug/million cells/0.1 mL
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