GITR / Tnfrsf18 (Mouse)(DTA-1), 0.2mg/mL, Clone: [DTA-1], Rat, Monoclonal

Product Overview

• Article Name: GITR / Tnfrsf18 (Mouse)(DTA-1), 0.2mg/mL, Clone: [DTA-1], Rat, Monoclonal
• Biozol Catalog Number: BOT-BNUB0976-500
• Supplier Catalog Number: BNUB0976-500
• Alternative Catalog Number: BOT-BNUB0976-500-500UL
• Manufacturer: Biotium
• Host: Rat
• Category: Antikörper
• Application: FC, Functional Studies
• Species Reactivity: Mouse
• Immunogen: Mouse CD25 CD4 T cells
• Alternative Names: Activation-inducible TNF-related ligand, AITRL, GITRL, Glucocorticoid induced TNFR related protein ligand, Glucocorticoid-induced TNF-related ligand, hGITRL, TL6, TNFSF18, Tumor necrosis factor (ligand) superfamily member 18

Product Description

GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25 CD4 Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25 CD4 Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

Product Properties

• Clonality: Monoclonal
• Concentration: 0.2 mg/mL
• Clone Designation: [DTA-1]
• Molecular Weight: 66-70 kDa (Homodimer)
• UniProt: O35714
• Buffer: PBS, 0.05% BSA, 0.05% azide
• Source: Animal

Application Notes

• Application Notes: Flow cytometry: 0.5-1 ug/million cells in 0.1 mL|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunofluorescence: 0.5-1 ug/mL|Optimal dilution for a specific application should be determined by user