DNMT1 / DNA Methyltransferase 1(DNMT1/2061), 0.2mg/mL, Clone: [DNMT1/2061], Mouse, Monoclonal
Biozol Catalog Number:
BOT-BNUB2061-100
Supplier Catalog Number:
BNUB2061-100
Alternative Catalog Number:
BOT-BNUB2061-100-100UL
Manufacturer:
Biotium
Host:
Mouse
Category:
Antikörper
Application:
IHC
Species Reactivity:
Human
Immunogen:
Recombinant human DNMT1 protein fragment (around aa 767-912) (exact sequence is proprietary)
Alternative Names:
ADCADN, AIM, CXXC-type zinc finger protein 9, CXXC9, DNA methyltransferase 1 (DNMT1), HSN1E, MCMT, Met1, MommeD2
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
