Calcineurin B / PPP3R1(BE2.1), 0.2mg/mL, Clone: [BE2.1], Mouse, Monoclonal
Biozol Catalog Number:
BOT-BNUB2321-100
Supplier Catalog Number:
BNUB2321-100
Alternative Catalog Number:
BOT-BNUB2321-100-100UL
Manufacturer:
Biotium
Host:
Mouse
Category:
Antikörper
Species Reactivity:
Human, Xenopus
Immunogen:
Recombinant full-length human Calcineurin B protein
Alternative Names:
Calcineurin B, Calcineurin subunit B type 1, Protein Phosphatase 3 Regulatory Subunit B Alpha, CALNB1, Cna2, CNB, CNB1, PPP3R1
This antibody recognizes the Calcineurin B alpha protein, encoded by the PPP3R1 (Protein Phosphatase 3 Regulatory Subunit B Alpha) gene. Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
For coating for ELISA, order Ab without BSA|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Optimal dilution and staining procedure for a specific application should be determined by user|Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry
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