RAD51 (Prognostic and Response to Chemotherapy Marker)(RAD51/2753), 0.2mg/mL, Clone: [RAD51/2753], Mouse, Monoclonal
Biozol Catalog Number:
BOT-BNUB2753-100
Supplier Catalog Number:
BNUB2753-100
Alternative Catalog Number:
BOT-BNUB2753-100-100UL
Manufacturer:
Biotium
Host:
Mouse
Category:
Antikörper
Application:
WB
Species Reactivity:
Human
Immunogen:
Recombinant fragment of human RAD51 protein (around aa 1-134) (exact sequence is proprietary)
Alternative Names:
RCA1/BRCA2 containing complex, subunit 5, BRCC5, DNA repair protein RAD51, FANCR, HsT16930, MRMV2, RAD51, RAD51 recombinase, RAD51A, RECA, RecA like protein, Recombination protein A
RAD51 is one of the key factors of DNA repair by homologous recombination and has been shown to have anti-apoptotic activity in tumor cells. RAD51 protein interacts with a variety of tumor suppressor proteins including p53, BRCA1 and BRCA2. Elevated expression of RAD51 enhances radio-resistance of human tumor cells. Overexpression of RAD51 protein in tumor cells renders them resistant against cytotoxic drugs like Cisplatin. RAD51 interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of RAD51. High-level expression of RAD51 has been observed in a variety of human malignancies. RAD51 overexpression correlates with histological grading of the tumor in invasive ductal mammary carcinoma. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
ELISA: For coating, order Ab without BSA, Western blot 1-2 ug/mL, Optimal dilution for a specific application should be determined.|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody
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