Lymphocyte Specific Protein 1 (LSP1) / pp52(LSP1/3042), 1mg/mL, Clone: [LSP1/3042], Mouse, Monoclonal

Product Overview

• Article Name: Lymphocyte Specific Protein 1 (LSP1) / pp52(LSP1/3042), 1mg/mL, Clone: [LSP1/3042], Mouse, Monoclonal
• Biozol Catalog Number: BOT-BNUM3042-50
• Supplier Catalog Number: BNUM3042-50
• Alternative Catalog Number: BOT-BNUM3042-50-50UL
• Manufacturer: Biotium
• Host: Mouse
• Category: Antikörper
• Species Reactivity: Human
• Immunogen: Recombinant fragment of human LSP1 protein (around aa174-278) (exact sequence is proprietary)
• Alternative Names: WP34, pp52, lymphocyte specific protein 1, leukocyte specific protein 1

Product Description

LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15. 5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5 terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Properties

• Clonality: Monoclonal
• Concentration: 1 mg/mL
• Clone Designation: [LSP1/3042]
• Molecular Weight: 52 kDa
• UniProt: P33241
• Buffer: PBS, no BSA, no azide
• Source: Animal

Application Notes

• Application Notes: For coating for ELISA, order Ab without BSA|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Optimal dilution and staining procedure for a specific application should be determined by user|Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry