Presenilin 1 Polyclonal Antibody, PE Conjugated, Rabbit
Biozol Catalog Number:
BSS-BS-0024R-PE
Supplier Catalog Number:
bs-0024R-PE
Alternative Catalog Number:
BSS-BS-0024R-PE-100
Manufacturer:
Bioss
Host:
Rabbit
Category:
Antikörper
Application:
FC, IF, WB
Species Reactivity:
Human, Mouse, Rat
Conjugation:
PE
Alternative Names:
AD3, FAD, PS1, PS-1, S182, Presenilin-1, Protein S182, PSEN1, PSNL1
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
