PS1, Ad3h, PS-1, S182, Presenilin-1, Protein S182, Psen1, Psnl1
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the