PTEN Polyclonal Antibody, Biotin Conjugated, Rabbit

Product Overview

• Article Name: PTEN Polyclonal Antibody, Biotin Conjugated, Rabbit
• Biozol Catalog Number: BSS-BS-0686R-BIOTIN
• Supplier Catalog Number: bs-0686R-Biotin
• Alternative Catalog Number: BSS-BS-0686R-BIOTIN-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, IHC-Fr, IHC-P, WB
• Species Reactivity: Mouse, Rat
• Conjugation: Biotin
• Alternative Names: Bannayan Zonana, BZS a, MGC11227, MHAM, MMAC1, Multiple hamartoma (Cowden syndrome), Mutated in Multiple Advanced Cancers 1, Phosphatase and Tensin Homolog, Phosphatidylinositol 345 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN, Phosphatidylinositol 345 trisphosphate 3 phosphatase, Platelet antigen BR, PTEN1, Tensin homolog, TEP1, VLA 2 Receptor Alpha Subunit, 10q23del, Bannayan Zonana syndrome, BZS, DEC, GLM2, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, Phosphatase and Tensin Homolog, Phosphatase and Tensin Homolog, Phosphatase and tensin like protein, Phosphatidylinositol 345 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN, Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, PTEN_HUMAN.

Product Description

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]

Product Properties

• Clonality: Polyclonal
• Concentration: 1ug/ul
• NCBI: 5728
• UniProt: P60484
• Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic peptide derived from human PTEN
• Target: PTEN

Application Notes

• Application Dilute: WB(1:300-5000), ELISA(1:500-1000), IHC-P(1:200-400), IHC-F(1:100-500)