AAV5 capsid protein VP1 Polyclonal Antibody, Biotin Conjugated, Rabbit
Biozol Catalog Number:
BSS-BS-10180R-BIOTIN
Supplier Catalog Number:
bs-10180R-Biotin
Alternative Catalog Number:
BSS-BS-10180R-BIOTIN-100
Manufacturer:
Bioss
Host:
Rabbit
Category:
Antikörper
Application:
ELISA, IHC-Fr, IHC-P
Species Reactivity:
Other, Virus
Conjugation:
Biotin
Alternative Names:
capsid protein Adeno-associated 5 virus, capsid protein [Adeno-associated virus - 5], capsid protein AAV5, Parvovirus coat protein VP1, capsid protein.
Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus
Clonality:
Polyclonal
Concentration:
1ug/ul
Buffer:
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Source:
KLH conjugated synthetic peptide derived from Adeno-Associated Virus 5 capsid protein VP1
