CIS-4, CIS4, Cish4, Cytokine inducible SH2 protein 4, Cytokine-inducible SH2 protein 4, HSPC060, SOCS-4, SOCS-6, SOCS4, Socs6, SOCS6_HUMAN, SSI4, STAI4, STAT induced STAT inhibitor 4, STAT4, STATI4, Suppressor of cytokine signaling 4, Suppressor of cytokine signaling 6.
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008].
