BAG9, Cancer associated surface antigen, Cancer associated surface antigen RCAS1, EB9, EBAG 9, Estrogen receptor binding fragment associated gene 9 protein, Estrogen receptor binding site associated antigen 9, PDAF, RCAS 1, RCAS1, Receptor binding cancer antigen expressed on SiSo cells.
This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor, which binds to the estrogen-responsive element found in the 5-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. This gene may also participate in the suppression of cell proliferation and inducing apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. Alternate splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 10.
