GRK4: G protein-coupled receptor kinase 4, G protein-coupled receptor kinase GRK4, GPRK2L, GPRK4 GRK5: G protein-coupled receptor kinase 5, G protein-coupled receptor kinase GRK5, GPRK5 GRK6: G protein-coupled receptor kinase 6, G protein-coupled receptor kinase GRK6, GPRK6
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation.
