AKR1C3 Polyclonal Antibody, Cy7 Conjugated, Rabbit

Product Overview

• Article Name: AKR1C3 Polyclonal Antibody, Cy7 Conjugated, Rabbit
• Biozol Catalog Number: BSS-BS-11401R-CY7
• Supplier Catalog Number: bs-11401R-Cy7
• Alternative Catalog Number: BSS-BS-11401R-CY7-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: IF, WB
• Species Reactivity: Rabbit
• Conjugation: Cy7
• Alternative Names: 17 beta HSD 5, 17 beta hydroxysteroid dehydrogenase type 5, 17-beta-HSD 5, 17-beta-hydroxysteroid dehydrogenase type 5, 2-dihydrobenzene-1, 2-diol dehydrogenase, 3 alpha hydroxysteroid dehydrogenase type II, 3-alpha-HSD type 2, 3-alpha-HSD type II, 3-alpha-HSD type II, brain, 3-alpha-hydroxysteroid dehydrogenase type 2, AK1C3_HUMAN, AKR1 C3, AKR1C3, Aldo keto reductase family 1 member C3, Aldo-keto reductase family 1 member C3, brain, Chlordecone reductase, Chlordecone reductase homolog HAKRb, DD-3, DD3, DDH1, DDX, Dihydrodiol dehydrogenase 3, Dihydrodiol dehydrogenase type I, Dihydrodiol dehydrogenase X, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, Indanol dehydrogenase, KIAA0119, PGFS, Prostaglandin F synthase, Testosterone 17-beta-dehydrogenase 5, Trans-1, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Type IIb 3 alpha hydroxysteroid dehydrogenase.

Product Description

DD3 is a unique enzyme that can specifically catalyze the dehydrogenation of trans-benzenedihydrodiol and trans-naphthalenedihydrodiol.Human liver contains isoforms of dihydrodiol dehydrogenase (DD1, DD2, DD3 and DD4), which belong to the aldo-oxo reductase/aldo-keto reductase (AKR) superfamily, have 20Alpha- or 3Alpha-hydroxysteroid dehydrogenase (HSD) activity. DD1 is also designated AKR1C1, DDH or DDH1 while DD2 also can be designated AKR1C2, dDD, BABP or DDH2. AKR1C3 and 3Alpha-HSD are alternate designations for DD3, while DD4 also can be called AKR1C4, CD or CHDR. DD1 and DD2 are 20Alpha-HSDs, whereas DD3 and DD4 are the 3Alpha-HSDs. The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics, such as polycyclic aromatic hydrocarbons, pesticides and steroid hormones, and are responsible for the reduction of ketone-containing drugs by using NADH or NADPH as a cofactor. The 20Alpha-HSD catalyzes the reaction of progesterone to the inactive form 20Alpha-hydroxyprogesterone. The 3Alpha-HSD is a cytosolic, monomeric, NADPH-dependent oxidoreductase that reduces 3-keto-5-dihydrosteroids to their tetrahydro products. DD1 and DD2 are ubiquitously expressed, whereas DD4 mRNA is restricted to the liver.

Product Properties

• Clonality: Polyclonal
• Concentration: 1ug/ul
• NCBI: 8644
• Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic peptide derived from human AKR1C3
• Target: AKR1C3

Application Notes

• Application Dilute: WB(1:300-5000), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)