16E1-BP, 16E1BP, Homo sapiens HPV16 E1 protein binding protein mRNA complete cds, HPV16 E1 protein binding protein, HPV16 E1 protein-binding protein, Human papillomavirus type 16 E1 protein binding protein, Human papillomavirus type 16 E1 protein-binding protein, Pachytene checkpoint protein 2 homolog, PCH2, Thyroid hormone receptor interactor 13, Thyroid receptor interacting protein 13, Thyroid receptor-interacting protein 13, TR-interacting protein 13, TRIP-13, Trip13, TRP13_HUMAN.
Thyroid hormone receptors (TRs) are transcription factors that regulate the expression of specific genes in a hormone-dependent manner. TRIP13 is a transcription factor that interacts with the ligand binding domain of the thyroid receptor (TR) as well as a variety of target genes including human papilloma virus type 16 (HPV16) E1. Unlike most TRIP proteins which function only in the presence of hormones, TRIP13 does not require the presence of thyroid hormone to interact with TR. The association of TRIP13 with (HPV16) E1 suggests that TRIP13 may have tumor suppressor gene function. TRIP13 is a 432 amino acid protein with 2 different isoforms produced by alternative splicing.
