amyloid beta precursor protein cytoplasmic tail binding protein 2, Amyloid beta precursor protein-binding protein 2, Amyloid protein binding protein 2, Amyloid protein-binding protein 2, APBP2_HUMAN, APP BP2, APP-BP2, Appbp2, PAT1, Ara67 Protein interacting with APP tail 1.
APPBP2 is a hydrophilic, microtubule binding protein that functions in the trafficking of Beta-Amyloid precursor protein. It is expressed in a variety of cell types and localizes to the cytoplasm. APPBP2 shares homology with kinesin light chain. It consists of a coiled-coil domain, PKC phosphorylation sites, four imperfect C-terminal tandem repeats, eight tetratricopeptide repeats and N- and C-terminal globular structures. APPBP2 recognizes and binds to the basolateral sorting sequence (BaSS) present in the cytoplasmic domain of the Beta-Amyloid precursor protein. In addition, APPBP2 interacts with the androgen receptor and suppresses androgen signaling.
