Serotonin (also designated 5-hydroxytryptamine or 5-HT) is a molecule that functions as a neurotransmitter, a hormone and a mitogen, and it is predominantly expressed in the gut, platelets and central nervous system (CNS). In the CNS, serotonin modulates several processes, including anxiety, sleep, appetite, behavior and drug abuse. In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. SR-3 is a ligand-gated ion channel, whereas all other known serotonin receptor subtypes are G protein-coupled receptors. Human SR-6 is one of the latest cloned receptors among the known SR receptors. ISR-6 is expressed in the limbic region, which is involved in the control of mood and emotion and in nervous system diseases such as depression and Alzheimers disease. The cellular mechanisms of SR-6 have not been clearly elucidated.
Clonality:
Polyclonal
Concentration:
1ug/ul
Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Source:
KLH conjugated synthetic peptide derived from human 5HT6 Receptor/SR-6
