phospho-APC (Ser2054) Polyclonal Antibody, Unconjugated, Rabbit

Product Overview

• Article Name: phospho-APC (Ser2054) Polyclonal Antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BSS-BS-12481R
• Supplier Catalog Number: bs-12481R
• Alternative Catalog Number: BSS-BS-12481R-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: IF, IHC-Fr, IHC-P
• Species Reactivity: Mouse, Rat
• Conjugation: Unconjugated
• Alternative Names: APC phospho S2054, p-APC phospho S2054, Adenomatous Polyposis Coli, APC, CC1, DP2, DP2.5, DP3, FAP, FPC, GS, Protein APC.

Product Description

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Product Properties

• Clonality: Polyclonal
• Concentration: 1ug/ul
• NCBI: 324
• Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic phosphopeptide derived from human APC around the phosphorylation site of Ser2054
• Target: phospho-APC (Ser2054)

Application Notes

• Application Dilute: IHC-P(1:200-400), IHC-F(1:100-500), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)