TMEPAI Polyclonal Antibody, Unconjugated, Rabbit

Product Overview

• Article Name: TMEPAI Polyclonal Antibody, Unconjugated, Rabbit
• Biozol Catalog Number: BSS-BS-12668R
• Supplier Catalog Number: bs-12668R
• Alternative Catalog Number: BSS-BS-12668R-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, IF, IHC-Fr, IHC-P, WB
• Species Reactivity: Human, Mouse
• Conjugation: Unconjugated
• Alternative Names: PMEPA_HUMAN, PMEPA1, Prostate transmembrane protein, androgen induced 1, Solid tumor associated 1 protein, Solid tumor-associated 1 protein, STAG1, TMEPAI, Transmembrane prostate androgen induced protein, Transmembrane prostate androgen-induced protein, Transmembrane, prostate androgen induced RNA.

Product Description

Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514).

Product Properties

• Clonality: Polyclonal
• Concentration: 1ug/ul
• NCBI: 56937
• UniProt: Q969W9
• Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic peptide derived from human TMEPAI
• Purity: Purified by Protein A.
• Target: TMEPAI
• Antibody Type: Primary Antibody

Application Notes

• Application Dilute: WB(1:300-5000), ELISA(1:500-1000), IHC-P(1:200-400), IHC-F(1:100-500), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)