ArPIKfyve, FLJ10305, FLJ36622, FLJ46582, MGC149815, MGC149816, OTTHUMP00000174908, Protein VAC14 homolog, Tax1 (human T cell leukemia virus type I) binding protein 1, Tax1 (human T cell leukemia virus type I) binding protein 2, Tax1 binding protein 2, Tax1-binding protein 2, TAX1BP2, TRX, VAC 14, vac14, Vac14 homolog (S. cerevisiae), Vac14 homolog, VAC14_HUMAN.
The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007 [PubMed 17556371]).[supplied by OMIM, Feb 2010]
