1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta 1, NDNC3, Phosphoinositide phospholipase C, Phosphoinositide phospholipase C delta 1, Phospholipase C delta 1, Phospholipase C III, PLC delta 1, PLC III. PLCD1_HUMAN
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
