C9orf142 Polyclonal Antibody, PE Conjugated, Rabbit
Biozol Catalog Number:
BSS-BS-15315R-PE
Supplier Catalog Number:
bs-15315R-PE
Alternative Catalog Number:
BSS-BS-15315R-PE-100
Manufacturer:
Bioss
Host:
Rabbit
Category:
Antikörper
Application:
IF, WB
Species Reactivity:
Mouse
Conjugation:
PE
Alternative Names:
C9orf142, Chromosome 9 open reading frame 142, CI142_HUMAN, Uncharacterized protein C9orf142.
C9orf142 (chromosome 9 open reading frame 142) is a 204 amino acid protein that exists as two alternatively spliced isoforms. The gene encoding C9orf142 maps to human chromosome 9q34.3. Chromosome 9 consists of about 145 million bases, represents 4% of the human genome and encodes nearly 900 genes. Thought to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias.
