phospho-STAT3 (Tyr705) Polyclonal Antibody, Biotin Conjugated, Rabbit

Product Overview

• Article Name: phospho-STAT3 (Tyr705) Polyclonal Antibody, Biotin Conjugated, Rabbit
• Biozol Catalog Number: BSS-BS-1658R-BIOTIN
• Supplier Catalog Number: bs-1658R-Biotin
• Alternative Catalog Number: BSS-BS-1658R-BIOTIN-100
• Manufacturer: Bioss
• Host: Rabbit
• Category: Antikörper
• Application: ELISA, IHC-Fr, IHC-P, WB
• Species Reactivity: Gallus, Human, Mouse, Rat
• Conjugation: Biotin
• Alternative Names: APRF, HIES, ADMIO, Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3

Product Description

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).

Product Properties

• Clonality: Polyclonal
• Concentration: 1ug/ul
• NCBI: 6774
• UniProt: P40763
• Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Source: KLH conjugated synthetic phosphopeptide derived from human STAT3 around the phosphorylation site of Tyr705
• Target: phospho-STAT3 (Tyr705)

Application Notes

• Application Dilute: WB(1:300-5000), ELISA(1:500-1000), IHC-P(1:200-400), IHC-F(1:100-500)