1500019G21Rik, FES1, Heat shock protein 70 binding protein, Heat shock protein 70 interacting protein, Heat shock protein binding protein 1, Heat shock protein-binding protein 1, Heat-shock 70-KD protein-binding protein 1, HPBP1_HUMAN, Hsp 70 binding protein, Hsp 70 interacting protein, Hsp70 binding protein 1, Hsp70 binding protein 2, Hsp70 interacting protein 1, Hsp70 interacting protein 2, Hsp70-binding protein 1, Hsp70-binding protein 2, Hsp70-interacting protein 1, Hsp70-interacting protein 2, HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1, HSPA-binding protein 1, HSPBP, HspBP1, HspBP2, PP1845.
Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
